Nodular Granulomatous Episcleritis

inflammation of the episcleral and adjacent tissues

What is it?
Nodular granulomatous episcleritis (NGE) is an immune-mediated (inflammatory) disease that affects the sclera, cornea and nictitans. 

Who is affected by it?
The condition is diagnosed most commonly in Collies, Cocker Spaniels, and related breeds. 

How is it treated?
Usually a combination of topical and oral anti-inflammatory and / or immunosuppressant medications is prescribed to treat the condition.  Once the episcleritis is in remission, the medications are slowly tapered over a period of several months to minimize the risk of recurrence. A treatment regimen using oral tetracycline and niacinamide (Vitamin B3) has also been described and appears to be fairly successful in causing regression of NGE in some patients over a period of weeks to months.   In severe cases surgical debulking of the nodules with cryotherapy (freezing procedure) may be necessary to induce remission.